SrasV1, France, Analysis, bibRecord, 000030

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

Identifieur interne : 000030 ( France/Analysis ); précédent : 000029; suivant : 000031

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

Auteurs : Christian A. Devaux [France] ; Jean-Marc Rolain [France] ; Philippe Colson [France] ; Didier Raoult [France]

Source :

International journal of antimicrobial agents [ 1872-7913 ] ; 2020.

RBID : pubmed:32171740

Abstract

Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.

DOI: 10.1016/j.ijantimicag.2020.105938
PubMed: 32171740

Affiliations:

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pubmed:32171740

Le document en format XML

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<front><div type="abstract" xml:lang="en">Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.</div>
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New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

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Abstract

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